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    Serial Ricinine Levels in Serum and Urine after Ricin Intoxication

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    1039203.pdf (649.3Kb)
    Date
    2013
    Author
    Røen, Bent Tore
    Opstad, Aase Mari
    Haavind, Anniken
    Tønsager, Janne
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    Abstract
    Ricinine is an alkaloid present in the castor bean plant (Ricinus communis) that can be used as a biomarker for ricin poisoning. Serial ricinine levels are reported in the serum and urine of a patient suffering from intentional ricin intoxication. The patient was brought to the hospital 4 h after injection and oral intake of a castor bean extract, but died 38 h later, despite intensive medical care. Ricinine was isolated from the samples by solid-phase extraction and quantitatively determined by isotopic dilution liquid chromatography–mass spectrometry. The ricinine level in serum declined from 33 to 23 ng/mL between 10 and 29 h post-exposure. Three urine samples collected from 12 to 41 h after ricin intoxication showed ricinine concentrations in the range of 20–58 ng/mL. The creatinine corrected values (21–30 µg/g) indicated a concentration–time profile with a maximum ricinine level in urine between 12 and 29 h after exposure.
    URI
    https://ffi-publikasjoner.archive.knowledgearc.net/handle/20.500.12242/29
    DOI
    10.1093/jat/bkt026
    Description
    Røen, Bent Tore; Opstad, Aase Mari; Haavind, Anniken; Tønsager, Janne. Serial Ricinine Levels in Serum and Urine after Ricin Intoxication. Journal of Analytical Toxicology 2013 ;Volum 37.(5) s. 313-317
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