Serial Ricinine Levels in Serum and Urine after Ricin Intoxication
MetadataShow full item record
Ricinine is an alkaloid present in the castor bean plant (Ricinus communis) that can be used as a biomarker for ricin poisoning. Serial ricinine levels are reported in the serum and urine of a patient suffering from intentional ricin intoxication. The patient was brought to the hospital 4 h after injection and oral intake of a castor bean extract, but died 38 h later, despite intensive medical care. Ricinine was isolated from the samples by solid-phase extraction and quantitatively determined by isotopic dilution liquid chromatography–mass spectrometry. The ricinine level in serum declined from 33 to 23 ng/mL between 10 and 29 h post-exposure. Three urine samples collected from 12 to 41 h after ricin intoxication showed ricinine concentrations in the range of 20–58 ng/mL. The creatinine corrected values (21–30 µg/g) indicated a concentration–time profile with a maximum ricinine level in urine between 12 and 29 h after exposure.
Røen, Bent Tore; Opstad, Aase Mari; Haavind, Anniken; Tønsager, Janne. Serial Ricinine Levels in Serum and Urine after Ricin Intoxication. Journal of Analytical Toxicology 2013 ;Volum 37.(5) s. 313-317