• Login
    View Item 
    •   FFI Publications Home
    • Publications
    • Articles
    • View Item
    •   FFI Publications Home
    • Publications
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Changes in fibrinogen availability and utilization in an animal model of traumatic coagulopathy

    View/Open
    1051158.pdf (327.1Kb)
    Date
    2013
    Author
    Hagemo, Jostein Skjalg
    Jørgensen, Jørgen J.
    Ostrowski, Sisse R.
    Holtan, Anders
    Gundersen, Yngvar
    Johansson, Pär I.
    Næss, Pål Aksel
    Gaarder, Christine
    Metadata
    Show full item record
    Abstract
    Background Impaired haemostasis following shock and tissue trauma is frequently detected in the trauma setting. These changes occur early, and are associated with increased mortality. The mechanism behind trauma-induced coagulopathy (TIC) is not clear. Several studies highlight the crucial role of fibrinogen in posttraumatic haemorrhage. This study explores the coagulation changes in a swine model of early TIC, with emphasis on fibrinogen levels and utilization of fibrinogen. Methods A total of 18 landrace pigs were anaesthetized and divided into four groups. The Trauma-Shock group (TS) were inflicted bilateral blast femoral fractures with concomitant soft tissue injury by a high-energy rifle shot to both hind legs, followed by controlled exsanguination. The Shock group (S) was exposed to shock by exsanguination, whereas a third group was exposed to trauma only (T). A fourth group (C) served as control. Physiological data, haematological measurements, blood gas analyses and conventional coagulation assays were recorded at baseline and repeatedly over 60 minutes. Thrombelastometry were performed by means of the tissue factor activated ExTEM assay and the platelet inhibiting FibTEM assay. Data were statistically analysed by repeated measurements analyses method. Results A significant reduction of fibrinogen concentration was observed in both the TS and S groups. INR increased significantly in the S group and differed significantly from the TS group. Maximum clot firmness (MCF) of the ExTEM assay was significantly reduced over time in both TS and S groups. In the FibTEM assay a significant shortening of the clotting time and an increase in MCF was observed in the TS group compared to the S group. Conclusion Despite a reduction in clotting capability measured by ExTEM MCF and a reduced fibrinogen concentration, extensive tissue trauma may induce an increased fibrin based clotting activity that attenuates the hypocoagulable tendency in exsanguinated animals.
    URI
    https://ffi-publikasjoner.archive.knowledgearc.net/handle/20.500.12242/37
    DOI
    10.1186/1757-7241-21-56
    Description
    Hagemo, Jostein Skjalg; Jørgensen, Jørgen Joakim; Ostrowski, Sisse R.; Holtan, Anders; Gundersen, Yngvar; Johansson, Pär I.; Næss, Pål Aksel; Gaarder, Christine. Changes in fibrinogen availability and utilization in an animal model of traumatic coagulopathy. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2013 ;Volum 21. s. -
    Collections
    • Articles

    Browse

    All of FFI PublicationsCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

    My Account

    Login

    CONTACT US

    • FFI Kjeller
      FFI, PO Box 25, 2027 Kjeller
    • Office Address: Instituttvn 20,
      Phone 63 80 70 00
    • biblioteket@ffi.no

    HELPFUL

    • About FFI
    • Career
    • Reports

    Sitemap

    • About cookies (cookies)
    • Newsletter
    • Sitemap

    FOLLOW US

     

     

    © Copyright Norwegian Defence Research Establishment
    Powered by KnowledgeArc