• Login
    View Item 
    •   FFI Publications Home
    • Publications
    • Rapporter
    • View Item
    •   FFI Publications Home
    • Publications
    • Rapporter
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Kontrollert mild/moderat hypotermi ved blødningssjokk

    View/Open
    00-05069.pdf (203.3Kb)
    Date
    2000
    Author
    Gundersen, Yngvar
    Vaagenes, Per
    Pharo, Anne
    Valø, Elisabeth Try
    Metadata
    Show full item record
    Abstract
    In a rat model of controlled haemorrhagic shock we have investigated the effects of therapeutic mild/moderate hypothermia on the early inflammatory response and organ function. In two groups of animals (n=13 in each group) volume-controlled haemorrhage was induced by a steady-state withdrawal of 2,5 ml/100 g body weight (plus 1 ml) from an arterial line over 10 minutes. The animals of the hypothermic group were simultaneously cooled to a temperature of 32.5-33.0 degrees C. After an observation period of 75 minutes 2/3 of the shed blood was reinjected. After resuscitation the animals were observed for two hours. As measured by the proximal cytokines TNF and IL-6, as well as the level of reactive oxygen species in peritoneal macrophages, hypothermia blunted the early inflammatory response. Based on parameters of liver and kidney function an organ-protective effect was observed. We conclude that hypothermia recuces the early cell-damaging consequences of haemorrhagic shock, partly due to its impact on the initial inflammatory response.
    URI
    http://hdl.handle.net/20.500.12242/1877
    Collections
    • Rapporter

    Browse

    All of FFI PublicationsCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

    My Account

    Login

    CONTACT US

    • FFI Kjeller
      FFI, PO Box 25, 2027 Kjeller
    • Office Address: Instituttvn 20,
      Phone 63 80 70 00
    • biblioteket@ffi.no

    HELPFUL

    • About FFI
    • Career
    • Reports

    Sitemap

    • About cookies (cookies)
    • Newsletter
    • Sitemap

    FOLLOW US

     

     

    © Copyright Norwegian Defence Research Establishment
    Powered by KnowledgeArc