Show simple item record

dc.contributor.authorKarl, J Philip
dc.contributor.authorMargolis, Lee M.
dc.contributor.authorMurphy, Nancy E.
dc.contributor.authorCarrigan, Christopher T
dc.contributor.authorCastellani, John W.
dc.contributor.authorMadslien, Elisabeth Henie
dc.contributor.authorTeien, Hilde Kristin
dc.contributor.authorMartini, Svein
dc.contributor.authorMontain, Scott J.
dc.contributor.authorPasiakos, Stefan M
dc.date.accessioned2017-09-18T08:20:49Z
dc.date.accessioned2017-09-20T06:47:50Z
dc.date.available2017-09-18T08:20:49Z
dc.date.available2017-09-20T06:47:50Z
dc.date.issued2017
dc.identifier.citationKarl JP, Margolis LM, Murphy NE, Carrigan CT, Castellani JW, Madslien EH, Teien HK, Martini S, Montain SJ, Pasiakos SM. Military training elicits marked increases in plasmametabolomic signatures of energy metabolism, lipolysis,fatty acid oxidation, and ketogenesis. Physiological Reports. 2017;5(17)en_GB
dc.identifier.urihttp://hdl.handle.net/20.500.12242/638
dc.identifier.urihttps://ffi-publikasjoner.archive.knowledgearc.net/handle/20.500.12242/638
dc.descriptionKarl, J Philip; Margolis, Lee M.; Murphy, Nancy E.; Carrigan, Christopher T; Castellani, John W.; Madslien, Elisabeth Henie; Teien, Hilde Kristin; Martini, Svein; Montain, Scott J.; Pasiakos, Stefan M. Military training elicits marked increases in plasma metabolomic signatures of energy metabolism, lipolysis, fatty acid oxidation, and ketogenesis. Physiological Reports 2017 ;Volum 5.(17)en_GB
dc.description.abstractMilitary training studies provide unique insight into metabolic responses to extreme physiologic stress induced by multiple stressor environments, and the impacts of nutrition in mediating these responses. Advances in metabolomics have provided new approaches for extending current understanding of factors modulating dynamic metabolic responses in these environments. In this study, whole‐body metabolic responses to strenuous military training were explored in relation to energy balance and macronutrient intake by performing nontargeted global metabolite profiling on plasma collected from 25 male soldiers before and after completing a 4‐day, 51‐km cross‐country ski march that produced high total daily energy expenditures (25.4 MJ/day [SD 2.3]) and severe energy deficits (13.6 MJ/day [SD 2.5]). Of 737 identified metabolites, 478 changed during the training. Increases in 88% of the free fatty acids and 91% of the acylcarnitines, and decreases in 88% of the mono‐ and diacylglycerols detected within lipid metabolism pathways were observed. Smaller increases in 75% of the tricarboxylic acid cycle intermediates, and 50% of the branched‐chain amino acid metabolites detected were also observed. Changes in multiple metabolites related to lipid metabolism were correlated with body mass loss and energy balance, but not with energy and macronutrient intakes or energy expenditure. These findings are consistent with an increase in energy metabolism, lipolysis, fatty acid oxidation, ketogenesis, and branched‐chain amino acid catabolism during strenuous military training. The magnitude of the energy deficit induced by undereating relative to high energy expenditure, rather than macronutrient intake, appeared to drive these changes, particularly within lipid metabolism pathways.en_GB
dc.language.isoenen_GB
dc.titleMilitary training elicits marked increases in plasmametabolomic signatures of energy metabolism, lipolysis,fatty acid oxidation, and ketogenesisen_GB
dc.typeArticleen_GB
dc.date.updated2017-09-18T08:20:49Z
dc.identifier.cristinID1494194
dc.identifier.cristinID1494194
dc.identifier.doi10.14814/phy2.13407
dc.source.issn2051-817X
dc.type.documentJournal article
dc.relation.journalPhysiological Reports


Files in this item

This item appears in the following Collection(s)

Show simple item record