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    Guidelines for using animal models in blast injury research

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    1647798.pdf (1002.Kb)
    Date
    2018
    Author
    Watts, Sarah
    Kirkman, Emrys
    Bieler, Dan
    Bjarnason, Stephen
    Franke, Axel
    Gupta, Raj Kumari
    Leggieri, Michael J.
    Orru, Hans
    Ouellet, Simon
    Philippens, Mat M. G. M.
    Sarron, Jean-Claude
    Skriudalen, Stian
    Teland, Jan Arild
    Risling, Mårten
    Cernak, Ibolja
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    Abstract
    Blast injury is a very complex phenomenon and frequently results in multiple injuries. One method to investigate the consequences of blast injuries is with the use of living systems (animal models). The use of animals allows the examination and evaluation of injury mechanisms in a more controlled manner, allowing variables such as primary or secondary blast injury for example, to be isolated and manipulated as required. To ensure a degree of standardisation across the blast research community a set of guidelines which helps researchers navigate challenges of modelling blast injuries in animals is required. This paper describes the guidelines for Using Animal Models in Blast Injury Research developed by the NATO Health Factors and Medicine (HFM) Research Task Group 234.
    URI
    http://hdl.handle.net/20.500.12242/2510
    DOI
    10.1136/jramc-2018-000956
    Description
    Watts, Sarah; Kirkman, Emrys; Bieler, Dan; Bjarnason, Stephen; Franke, Axel; Gupta, Raj Kumari; Leggieri, Michael J.; Orru, Hans; Ouellet, Simon; Philippens, Mat M. G. M.; Sarron, Jean-Claude; Skriudalen, Stian; Teland, Jan Arild; Risling, Mårten; Cernak, Ibolja. Guidelines for using animal models in blast injury research. Journal of the Royal Army Medical Corps 2018
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