Search
Now showing items 1-9 of 9
Pretreatment and prophylaxis against nerve agent poisoning: are undesirable behavioral side effects unavoidable?
(2016)
The threat of chemical warfare agents like nerve agents requires life saving measures of medical pretreatment combined with treatment after exposure. Pretreatment (pyridostigmine) may cause some side effects in a small ...
Choice of approaches in developing novel medical countermeasures for nerve agent poisoning
(2014)
During the establishment of a research branch, all relevant matters encountered will be of interest to study. After having acquired a body of basal knowledge, it becomes possible to derive ideas or hypotheses for further ...
Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility
(2013)
A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman ...
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats
(2015)
A treatment regimen consisting of HI-6, levetiracetam, and procyclidine (termed the triple regimen) has previously been shown to work as a universal therapy against soman poisoning in rats, since it has capacities to ...
Behavioral side effects of prophylactic therapies against soman-induced seizures and lethality in rats
(2014)
Four medical therapies previously shown to exert varying degrees of protection against a convulsant dose of soman were assessed for potential behavioral side effects in a novelty test. In Experiment 1, HI-6 (1-[([4-(amin ...
The perirhinal cortex of rats: An intricate area for microinfusion of anticonvulsants against soman-induced seizures
(2013)
Microinfusion of anticonvulsants into the perirhinal cortex through 1 guide cannula in each hemisphere only invades a small area of this seizure controlling site in rats exposed to soman. The purpose of the present study ...
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats
(2013)
The mechanisms underlying insulin sensitivity and fat tissue distribution in chronic renal insufficiency remain unclear. Previous studies have shown the benefits of angiotensin II receptor blockers on moderately nourished ...
Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention
(2018-12-19)
Compounds that cause powerful sensory irritation to humans were reviewed by the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) in response to requests in 2014 and 2017 ...
Development of neuropathology following soman poisoning and medical countermeasures
(2018)
Nerve agent-induced seizures can cause varying degrees of neuropathology depending on level of poisoning and duration of seizing. The intention of this review was to validate a novel approach for establishing effective ...