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Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility
(2013)
A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman ...
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats
(2015)
A treatment regimen consisting of HI-6, levetiracetam, and procyclidine (termed the triple regimen) has previously been shown to work as a universal therapy against soman poisoning in rats, since it has capacities to ...
Behavioral side effects of prophylactic therapies against soman-induced seizures and lethality in rats
(2014)
Four medical therapies previously shown to exert varying degrees of protection against a convulsant dose of soman were assessed for potential behavioral side effects in a novelty test. In Experiment 1, HI-6 (1-[([4-(amin ...
The perirhinal cortex of rats: An intricate area for microinfusion of anticonvulsants against soman-induced seizures
(2013)
Microinfusion of anticonvulsants into the perirhinal cortex through 1 guide cannula in each hemisphere only invades a small area of this seizure controlling site in rats exposed to soman. The purpose of the present study ...
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats
(2013)
The mechanisms underlying insulin sensitivity and fat tissue distribution in chronic renal insufficiency remain unclear. Previous studies have shown the benefits of angiotensin II receptor blockers on moderately nourished ...