Browsing by Author "Opstad, Per Kristian"
Now showing items 1-6 of 6
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Calprotectin (S100A8/S100A9) and myeloperoxidase: Co-regulators of formation of reactive oxygen species
Bøyum, Arne; Skrede, Knut Kristian; Myhre, Oddvar; Tennfjord, Vivi-Ann; Neurauter, Christine Gran; Tolleshaug, Helge; Knudsen, Eirunn; Opstad, Per Kristian; Bjørås, Magnar; Benestad, Haakon Breien (2010)Inflammatory mediators trigger polymorphonuclear neutrophils (PMN) to produce reactive oxygen species (ROS: O2-, H2O2, ∙OH). Mediated by myeloperoxidase in PMN, HOCl is formed, detectable in a chemiluminescence (CL) assay. ... -
Maternal deprivation of Lewis rat pups increases the severity of experimental periodontitis in adulthood
Breivik, Torbjørn; Gundersen, Yngvar; Murison, Robert; Turner, Jonathan D.; Muller, Claude P.; Gjermo, Per E; Opstad, Per Kristian (2015)Background and Objective: Early life adverse events may influence susceptibility/resistance to chronic inflammatory diseases later in life by permanently dysregulating brain-controlled immune-regulatory systems. We ... -
Plasma Cytokine Profiles in Long-Term Strenuous Exercise
Nielsen, Hilde Grindvik; Øktedalen, Olav; Opstad, Per Kristian; Lyberg, Torstein (2016)The open window theory indicates altered immunity 3 to 72 hours after exercise. The J-curve describes the risk of illness in response to exercise. The aim of this study was to examine the secretion of proinflammatory and ... -
Response of circulating immune cells to major gunshot injury, haemorrhage, and acute surgery
Gundersen, Yngvar; Vaagenes, Per; Thrane, Ingjerd; Bogen, Inger Lise; Haug, Kristin Huse; Reistad, Trine; Opstad, Per Kristian (2005)Purpose: The purpose of this study was to use an established porcine model to investigate the effects on immune function of severe gunshot injury. Methods: Twelve pigs sustained two standardised rounds, one through ... -
Severe gunshot injuries in a porcine model: impact on central markers of innate immunity
LUNDELAND, BÅRD; Gundersen, Yngvar; Opstad, Per Kristian; Thrane, Ingjerd; Zhang, Ying; Olaussen, Richard W; Vaagenes, Per (2011)Background The mechanisms behind lipopolysaccharide (LPS) tolerance remain obscure. LPS signals through Toll-like receptor 4 (TLR4) and severe trauma/haemorrhage may influence binding and signalling through this receptor, ... -
Systemic Chemical Desensitization of Peptidergic Sensory Neurons with Resiniferatoxin Inhibits Experimental Periodontitis
Breivik, Torbjørn; Gundersen, Yngvar; Gjermo, Per E; Fristad, Inge; Opstad, Per Kristian (2011)Background and objective: The immune system is an important player in the pathophysiology of periodontitis. The brain controls immune responses via neural and hormonal pathways, and brain-neuro-endocrine dysregulation ...