Browsing by Author "Ring, Avi"
Now showing items 1-4 of 4
-
Bispyridinium compounds inhibit both muscle and neuronal nicotinic acetylcholine receptors in human cell lines
Ring, Avi; Strøm, Bjørn Oddvar; Turner, Simon R.; Timperley, Christopher M.; Bird, Michael; Green, A. Christopher; Chad, John E.; Worek, Franz; Tattersall, John E.H. (2015)Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which ... -
Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling
Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (2019-05-30)N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional ... -
Investigation of new orexin 2 receptor modulators using in silico and in vitro methods
Janockova, Jana; Dolezal, Rafael; Nepovimova, Eugenie; Kobrlova, Tereza; Benkova, Marketa; Kuca, Kamil; Konecny, Jan; Mezeiova, Eva; Melikova, Michaela; Hepnarova, Vendula; Ring, Avi; Soukup, Ondrej; Korabecny, Jan (2018)The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors. Generally, the primary role of orexins is to act as ... -
Microvesicle Shedding and Lysosomal Repair Fulfill Divergent Cellular Needs during the Repair of Streptolysin O-Induced Plasmalemmal Damage
Atanassoff, Alexander P.; Wolfmeier, Heidi; Schoenauer, Roman; Hostettler, Andrea; Ring, Avi; Draeger, Annette; Babiychuk, Eduard B. (2014)Pathogenic bacteria secrete pore-forming toxins that permeabilize the plasma membrane of host cells. Nucleated cells possess protective mechanisms that repair toxin-damaged plasmalemma. Currently two putative repair scenarios ...