Browsing by Author "Myhrer, Trond"
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Aktuelle motmidler mot hjerneskader ved nervegasseksponering
Aas, Pål; Myhrer, Trond (2003)The potential for exposure to chemical warfare nerve agents exists on the battlefield and as a terrorist threat to civilians. Nerve agents are irreversible inhibitors of the acetylcholinesterase enzyme and there-by induce ... -
Behavioral side effects of prophylactic therapies against soman-induced seizures and lethality in rats
Myhrer, Trond; Enger, Siri; Aas, Pål (2014)Four medical therapies previously shown to exert varying degrees of protection against a convulsant dose of soman were assessed for potential behavioral side effects in a novelty test. In Experiment 1, HI-6 (1-[([4-(amin ... -
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats
Myhrer, Trond; Mariussen, Espen; Enger, Siri; Aas, Pål (2013)The mechanisms underlying insulin sensitivity and fat tissue distribution in chronic renal insufficiency remain unclear. Previous studies have shown the benefits of angiotensin II receptor blockers on moderately nourished ... -
Choice of approaches in developing novel medical countermeasures for nerve agent poisoning
Myhrer, Trond; Aas, Pål (2014)During the establishment of a research branch, all relevant matters encountered will be of interest to study. After having acquired a body of basal knowledge, it becomes possible to derive ideas or hypotheses for further ... -
Development of neuropathology following soman poisoning and medical countermeasures
Myhrer, Trond; Mariussen, Espen; Aas, Pål (2018)Nerve agent-induced seizures can cause varying degrees of neuropathology depending on level of poisoning and duration of seizing. The intention of this review was to validate a novel approach for establishing effective ... -
Evaluering av tre typer autoinjektor-regimer mot nervegassforgiftning
Aas, Pål; Enger, Siri; Myhrer, Trond (2011-12-15)Forsvaret er utstyrt med akuttmedisinske motmidler som har til formål å redusere skader på mennesker og å øke overlevelse etter nervegasseksponering. Dette er legemidler som skal benyttes både profylaktisk og i oppfølgende ... -
Legemidler i supplerende medisinsk behandling ved nervegassforgiftning : aktuelle legemidler i beskyttelse av hjernen
Aas, Pål; Myhrer, Trond; Heyerdahl, Fridtjof (2009)Dersom nervegasser blir benyttet mot forsvarets personell eller mot sivile, er det viktig at man så raskt som mulig kan ta i bruk medikamenter for å redusere skadeomfanget. Forsvaret er utstyrt med nødvendige akuttmedisinske ... -
The perirhinal cortex of rats: An intricate area for microinfusion of anticonvulsants against soman-induced seizures
Myhrer, Trond; Enger, Siri; Aas, Pål (2013)Microinfusion of anticonvulsants into the perirhinal cortex through 1 guide cannula in each hemisphere only invades a small area of this seizure controlling site in rats exposed to soman. The purpose of the present study ... -
Pretreatment and prophylaxis against nerve agent poisoning: are undesirable behavioral side effects unavoidable?
Myhrer, Trond; Aas, Pål (2016)The threat of chemical warfare agents like nerve agents requires life saving measures of medical pretreatment combined with treatment after exposure. Pretreatment (pyridostigmine) may cause some side effects in a small ... -
Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats
Myhrer, Trond; Mariussen, Espen; Enger, Siri; Aas, Pål (2015)A treatment regimen consisting of HI-6, levetiracetam, and procyclidine (termed the triple regimen) has previously been shown to work as a universal therapy against soman poisoning in rats, since it has capacities to ... -
Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility
Myhrer, Trond; Enger, Siri; Mariussen, Espen; Aas, Pål (2013)A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman ...