Browsing by Author "Frøland, Anne-Sofie"

Now showing items 1-2 of 2

Glyceraldehyde metabolism in mouse brain and the entry of blood-borne glyceraldehyde into the brain

Hassel, Bjørnar; Sørnes, Kristian; Elsais, Ahmed; Cordero, Patricia Reyes; Frøland, Anne-Sofie; Rise, Frode (2024-06-22)

D-Glyceraldehyde, a reactive aldehyde metabolite of fructose and glucose, is neurotoxic in vitro by forming advanced glycation end products (AGEs) with neuronal proteins. In Alzheimer's disease brains, glyceraldehyde-containing ...
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia

Morland, Cecilie; Frøland, Anne-Sofie; Nguyen, Mi Mong Tran; Storm-Mathisen, Jon; Gundersen, Vidar; Rise, Frode; Hassel, Bjørnar (2018)

Propionic acidemia is the accumulation of propionate in blood due to dysfunction of propionyl-CoA carboxylase. The condition causes lethargy and striatal degeneration with motor impairment in humans. How propionate exerts ...